The FDA recently issued as recommendation that bedtime doses of zolpidem (AMBIEN) be lowered because new data show that blood levels in some patients may be high enough in the morning after use to impair activities that require alertness, including driving. Based on this recommendation orders written will be substituted as follows:
AMBIEN 10 mg → AMBIEN 5 mg
AMBIEN CR 12.5 mg → AMBIEN CR 6.25 mg
All pre-printed order sets are being changed to the lower dose as well. If physicians choose to keep their patients on the higher doses of zolpidem, they need to indicate “no substitution”.