Tag Archives: clostridium difficile

Research Shows Probiotics Do Not Limit Antibiotic Associated Diarrhea or C. dif Diarrhea

Do probiotics prevent antibiotic associated diarrhea? A Welsh study published in The Lancet indicates that antibiotic-induced diarrhea is not prevented in the elderly by a daily dose of probiotics. Earlier research had shown potential, and prompted doctors to routinely prescribe antibiotics and probiotics together. The probiotic market had been estimated to reach $2.07 billion by 2015.

Approximately 10.8% of people in the probiotic group got antibiotic-associated diarrhea, compared to 10.4% of the control group. Researcher Stephen J. Allen concluded, “Our findings should discourage the use of microbial preparations for the prevention of AAD and C. difficile diarrhea.” He believes previous research showing promise was flawed because of microbial variation, small sample sizes, erroneous reporting, and poor trial designs.



A lecture on outbreaks in extended care facilities

This is the screen cast of a lecture titled “Outbreaks in extended care facilities (ECF)” given by Irfan Hafiz MD on April 19th 2013 at Centegra McHenry Hospital. It was co-sponsored by Centegra Health System and the McHenry County Dept. of Health.

Topics included in the lecture include:

  • Identifying current and emerging infectious disease common to long term care facilities (LTCF).
  • Describe preventive interventions for infectious disease in the context of LTCF.
  • Describe the unique challenges facing LTCF in the context of infectious diseases.

For upcoming lectures please look at the calendar and filter by “Education Events”.


Duodenal infusion of donor feces for recurrent Clostridium difficile


Recurrent refractory Clostridium difficile infection has been a cause of significant morbidity. There have been years of anecdotal case reports of successful fecal transplant.[1][2][3] This study [4] published in the January 31st 2013 issue of New England Journal of Medicine describes resolution of symtoms in 13 of 16 patients treated with single duodenal infusion of feces.
Feces was collected on the day of infusion from prescreened volunteers, processed and administered within 6 hours of collection via nasoduodenal tube. The feces was diluted with 500 ml of sterile water, stirred, strained before administration.
All patients in the study first received oral vancomycin followed by bowel prep with 4 liters of macrogol solution on the last day of antibiotic treatment.