Do probiotics prevent antibiotic associated diarrhea? A Welsh study published in The Lancet indicates that antibiotic-induced diarrhea is not prevented in the elderly by a daily dose of probiotics. Earlier research had shown potential, and prompted doctors to routinely prescribe antibiotics and probiotics together. The probiotic market had been estimated to reach $2.07 billion by 2015.
Approximately 10.8% of people in the probiotic group got antibiotic-associated diarrhea, compared to 10.4% of the control group. Researcher Stephen J. Allen concluded, “Our findings should discourage the use of microbial preparations for the prevention of AAD and C. difficile diarrhea.” He believes previous research showing promise was flawed because of microbial variation, small sample sizes, erroneous reporting, and poor trial designs.
- Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial; The Lancet, Early Online Publication, 8 August 2013 doi:10.1016/S0140-6736(13)61218-0
- Bloomberg News (8/7, Fourcade)
- MedPage Today (8/8)