Rapid tPA Treatment May Benefit Stroke Patients

Research by Saver et al published in the June 19th 2013 issue of the Journal of the American Medical Association shows that rapid treatment with a clot-dissolving drug reduces stroke patients’ risk of in-hospital death and increases their chances of being able to walk and return home when they leave the hospital. Data was reviewed from more than 58,000 patients who suffered an ischemic stroke and were treated with tissue plasminogen activator within four and a half hours of the onset of stroke symptoms. Researchers found that for every 15-minute faster start of tPA therapy, patients were less likely to die or have an intracranial hemorrhage, and were more likely to walk and be sent home when discharged from the hospital.


Saver JL, Fonarow GC, Smith EE, et al. Time to Treatment With Intravenous Tissue Plasminogen Activator and Outcome From Acute Ischemic StrokeJAMA.2013;309(23):2480-2488. doi:10.1001/jama.2013.6959.