Duodenal infusion of donor feces for recurrent Clostridium difficile

20130420-182119.jpg

Recurrent refractory Clostridium difficile infection has been a cause of significant morbidity. There have been years of anecdotal case reports of successful fecal transplant.[1][2][3] This study [4] published in the January 31st 2013 issue of New England Journal of Medicine describes resolution of symtoms in 13 of 16 patients treated with single duodenal infusion of feces.
Feces was collected on the day of infusion from prescreened volunteers, processed and administered within 6 hours of collection via nasoduodenal tube. The feces was diluted with 500 ml of sterile water, stirred, strained before administration.
All patients in the study first received oral vancomycin followed by bowel prep with 4 liters of macrogol solution on the last day of antibiotic treatment.